Author

Alexander I. M. Sever

University of TorontoORCID 0000-0001-9740-4113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Hanlin WangiD· 1 shared Huaying ZhaoiD· 1 shared James M. AraminiiD· 1 shared Jeffrey P. BoniniD· 1 shared John L. RubinsteiniD· 1 shared Lewis E. KayiD· 1 shared Peter SchuckiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

Hanlin WangORCID

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1 paper

Recent·Most cited

The dynamic and heterogeneous structure of the non-canonical inflammasome

Alexander I. M. Sever, James M. Aramini, Jeffrey P. Bonin, Huaying Zhao, Hanlin Wang, John L. Rubinstein, Peter Schuck, Lewis E. Kay

This paper determines the structure and dynamics of the non-canonical inflammasome using biophysical methods, showing it is heterogeneous and primed for rapid substrate cleavage.

Proceedings of the National Academy of Sciences · Aug 3, 2026Peer-reviewedBiophysics