Author

Jeffrey P. Bonin

University of TorontoORCID 0000-0002-2138-4440Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Lewis E. KayiD· 2 shared Alexander I. M. SeveriD· 1 shared Bernd BukauiD· 1 shared Hanlin WangiD· 1 shared Huaying ZhaoiD· 1 shared James M. AraminiiD· 1 shared Jin Sub LeeiD· 1 shared John L. RubinsteiniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Lewis E. KayORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Phase separation reshapes the conformational energy landscape of a chaperone to prime its activity

Rashik Ahmed, Lucia Svoboda, Rhea P Hudson, Jeffrey P. Bonin, Bernd Bukau, Julie Deborah Forman-Kay, Lewis E. Kay

This study shows how phase separation alters the conformational dynamics of DNAJB1, priming it for HSP70 binding and stress granule disassembly.

bioRxiv · Oct 22, 2026 · PreprintBiophysics

The dynamic and heterogeneous structure of the non-canonical inflammasome

Alexander I. M. Sever, James M. Aramini, Jeffrey P. Bonin, Huaying Zhao, Hanlin Wang, John L. Rubinstein, Peter Schuck, Lewis E. Kay

This paper determines the structure and dynamics of the non-canonical inflammasome using biophysical methods, showing it is heterogeneous and primed for rapid substrate cleavage.

Proceedings of the National Academy of Sciences · Aug 3, 2026Peer-reviewedBiophysics

Making invisible excited state protein structures visible by combining NMR and machine learning

Jeffrey P. Bonin, Jin Sub Lee, Zi Hao Liu, Philip M. Kim, Lewis E. Kay

The paper combines NMR data with AlphaFlow to identify excited state conformers of pro-IL-18, revealing structural insights from transient states.

bioRxiv · Nov 27, 2025 · PreprintBiophysics