Author

Frederic D. Darios

Centre National de la Recherche ScientifiqueORCID 0000-0001-9800-5990Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Dominic Samaroo· 2 shared Margaux Cauhapé· 2 shared Alexandra DürriD· 1 shared Alexia MenuetiD· 1 shared Belinda Simone CowlingiD· 1 shared Benoît ColschiD· 1 shared Filippo Maria SantorelliiD· 1 shared Giovanni StévaniniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Dominic Samaroo

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 21, 2025

SPG11 models reveal lysosomal calcium as a regulator of neural progenitor proliferation

Dominic Samaroo, Margaux Cauhapé, Léa Bernachot, Frederic D. Darios

This study shows that SPG11 mutations cause lysosomal calcium accumulation, reducing neural progenitor proliferation and affecting mTOR signaling in cortical development.

DOI 10.1101/2025.07.21.665525

mousespatial transcriptomics

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NeurosciencebioRxivPreprintJan 29, 2024

Decreasing ganglioside synthesis delays motor and cognitive symptom onset in Spg11 knockout mice

Manon Fortier, Margaux Cauhapé, Suzie Buono…·Frederic D. Darios

This study shows that reducing ganglioside synthesis delays motor and cognitive symptoms in Spg11 knockout mice and reduces axonal spheroids.

DOI 10.1101/2024.01.29.577736

mouseexperimental assay

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