Alexander Brace

This study uses molecular dynamics simulations and AI/ML to elucidate how nsp10 activates nsp16's methylation function by stabilizing its SAM pocket and enabling RNA binding.

This paper develops a deep learning method to identify progress coordinates during weighted ensemble simulations, improving folding rate constant estimation by >3-fold in protein folding simulations.

GenSLMs use large language models to analyze SARS-CoV-2 genomes, enabling rapid identification of variants of concern and providing insights into evolutionary dynamics.

This paper develops a machine learning framework using genome annotations to predict bacterial phenotypes, achieving high accuracy for Gram-stain type and respiration type.