Mónica Rosas‐Lemus

SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

This study shows SARS-CoV-2 ORF3a disrupts lysosomal cholesterol export by interfering with VPS39-regulated NPC2 trafficking and BMP metabolism.

HSD17B11 maintains FSP1 localization on lipid droplets to support ferroptosis defense

This study identifies HSD17B11 as a regulator that maintains FSP1 localization on lipid droplets, supporting ferroptosis defense.

Mechanistic insights into the association and activation of the SARS-CoV-2 2'-O-Methyltransferase (NSP16)

This study uses molecular dynamics simulations and AI/ML to elucidate how nsp10 activates nsp16's methylation function by stabilizing its SAM pocket and enabling RNA binding.

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

The paper resolves the x-ray structure of SARS-CoV and SARS-CoV-2 SUD-N/M domains and shows they have rotational flexibility, with disulfide bonds absent in pangolin-SARS and related viruses.

A mechanism that transduces lysosomal damage signals to stress granule formation for cell survival

The paper identifies a calcium-dependent pathway involving ALIX that links lysosomal damage to stress granule formation, promoting cell survival in response to various stressors.

Methylation of RNA Cap in SARS-CoV-2 captured by serial crystallography

The paper determines the crystal structures of SARS-CoV-2 Nsp10/16 complexes before and after methylation, revealing the mechanism of RNA capping and its role in viral evasion of host defenses.