Author

Clil Regev

Frederick National Laboratory for Cancer ResearchORCID 0000-0001-9879-1936Unclaimed ORCID profile · follow to get notified of new preprints

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1 Approach:statistical model· 1

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Hyunbum JangiD· 1 shared Ruth NussinoviD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperMolecular Biology

Hyunbum JangORCID

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1 paper

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Molecular BiologyJournal of Molecular BiologyPeer-reviewedApr 9, 2025

ERK Allosteric Activation: The Importance of Two Ordered Phosphorylation Events

Clil Regev, Hyunbum Jang, Ruth Nussinov

This study uses molecular dynamics simulations to show that ERK activation requires ordered phosphorylation events, with threonine phosphorylation as the second step being essential for catalytic activity.

11 citations

protein structurestatistical model

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