Qingyuan Zhao

Causal mediation analysis for time-varying heritable risk factors with Mendelian Randomization

FLOW-MR estimates causal effects of time-varying risk factors using GWAS summary statistics, revealing BMI's childhood protective effect on breast cancer and evolving impacts on stroke risk.

PathGPS: Discover shared genetic architecture using biobank data

PathGPS uses GWAS summary data to identify genetic architecture by separating genetic components from environmental factors and finding gene-trait clusters associated with biological pathways.

Profile-likelihood Bayesian model averaging for two-sample summary data Mendelian randomization in the presence of horizontal pleiotropy

This paper develops a Bayesian model averaging approach for Mendelian randomization to address horizontal pleiotropy, demonstrating its application to study cholesterol's causal role in age-related macular degeneration.

Causal Inference for Heritable Phenotypic Risk Factors Using Heterogeneous Genetic Instruments

This paper introduces GRAPPLE, a framework for causal inference using heterogeneous genetic instruments, and applies it to study the causal effects of blood lipids, BMI, and systolic blood pressure on 25 diseases.

A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

This study uses Mendelian randomization to assess the causal effects of lipoprotein subfractions on coronary artery disease risk, finding protective effects for certain HDL particle traits.