Author

Zixuan Wu

University of ChicagoORCID 0009-0006-4745-0000Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Assay:GWAS summary statistics· 2 Approach:statistical model· 2

Frequent Co-Authors

Jingshu WangiD· 2 shared Ethan LewisiD· 1 shared Qingyuan ZhaoiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersGenetics

Jingshu WangORCID

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2 papers

Recent·Most cited

GeneticsNature CommunicationsPeer-reviewedJul 28, 2025

Causal mediation analysis for time-varying heritable risk factors with Mendelian Randomization

Zixuan Wu, Ethan Lewis, Qingyuan Zhao, Jingshu Wang

FLOW-MR estimates causal effects of time-varying risk factors using GWAS summary statistics, revealing BMI's childhood protective effect on breast cancer and evolving impacts on stroke risk.

8 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 9, 2024

Validity and Interpretation of Two-Sample Mendelian Randomization with Binary Traits

Zixuan Wu, Jingshu Wang

This paper provides a formal statistical justification for using two-sample Mendelian randomization with binary traits by showing that standard methods estimate scaled causal effects on an underlying liability scale.

3 citations

GWAS summary statisticsstatistical model

𝕏 PostBluesky