Author

Sudip Roy

ORCID 0000-0001-9930-081XUnclaimed ORCID profile · follow to get notified of new preprints

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Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

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Jayant Kumar SinghiD· 1 shared Malay Ranjan BiswaliD· 1 shared

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1 shared paperBiophysics

Jayant Kumar SinghORCID

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BiophysicsbioRxivPreprintSep 25, 2024

In Silico Engineering of Stable siRNA Lipid Nanoparticles: Exploring the Impact of Ionizable Lipid Concentrations for Enhanced Formulation Stability

Malay Ranjan Biswal, Sudip Roy, Jayant Kumar Singh

This study uses molecular dynamics simulations to show that LNPs with positive ionizable lipids encapsulate more siRNA and require less force for siRNA escape compared to neutral lipids.

4 citations

statistical modelmechanistic / dynamical model

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