Sharath C. Madasu

The paper shows that mGluR1 can increase Kv1.2 surface expression independently of agonist through a PKA-dependent pathway, and that this effect is inhibited by PKA inhibitors and an inverse agonist.

The paper identifies mGluR1-associated proteins interacting with Kv1.2 and shows PKC mediates Kv1.2 regulation in the cerebellum through phosphorylation and endocytosis.