Tetsushi Nakao

This study integrates common and rare variant mapping across diverse populations to identify novel therapeutic targets, finding NRG4 as a candidate for preserving kidney function.

This study evaluates polygenic risk scores for cardiovascular diseases in predicting carotid stenosis, finding that PAD and CAD PRSs show significant associations and improved discrimination over traditional risk factors.

This study examines associations between leukocyte telomere length and genomic, phenomic, and geographic factors in diverse U.S. populations, identifying novel loci and genes.

The paper identifies plasma proteins associated with clonal hematopoiesis and links them to cardiovascular disease through proteomic and genetic analyses.

This paper develops a polygenic score for peripheral artery disease (PAD) that improves risk prediction across diverse populations and identifies high-risk individuals for adverse limb events.

ALADYNOULLI integrates longitudinal health records and genetic data to model disease progression, identifying interpretable disease signatures with cross-population consistency and improving clinical prediction.

The paper identifies IL1RAP and AIM2 as key modifiers of CHIP-associated cardiovascular risk using UK Biobank data and CRISPR experiments in mice.

This study analyzes clonal hematopoiesis in over a million diverse individuals, identifying 72 genome-wide significant loci and linking CHIP to various phenotypes.

The paper uses bidirectional Mendelian randomization to show LTL lengthening increases CHIP risk, while CHIP accelerates LTL shortening, with modest mediation between CHIP and CAD via LTL.