Ladislav Vyklický

This study identifies potent NMDAR positive modulators by modifying the pregnenolone scaffold with C-20 oxime ethers, showing improved efficacy and drug-like properties compared to PES.

This study characterizes a mouse model with a GluN2B protein-truncating variant, showing reduced NMDAR function and moderate behavioral effects.

This study creates zebrafish models of GluN2A loss of function and finds altered locomotor behavior and changes in NMDAR subunit composition.