Spatial multi-omics implicates vascular adipocytes proximal to tertiary lymphoid structures in human aortic aneurysm and B-cell autoreactivity.
Akshaya K. Meher, Weihua Huang, Dean J. Yamaguchi, Changhong Yin, Madison M. Swyers, Gabriel S. Dubis, Li V. Yang, Mark D. Mannie, Coleen A. McNamara
This study uses spatial multi-omics to show that vascular adipocytes near tertiary lymphoid structures in human aortic aneurysms contribute to B-cell autoreactivity and inflammation.
bioRxiv · Oct 23, 2026 · PreprintImmunology