Li V. Yang

Spatial multi-omics implicates vascular adipocytes proximal to tertiary lymphoid structures in human aortic aneurysm and B-cell autoreactivity.

This study uses spatial multi-omics to show that vascular adipocytes near tertiary lymphoid structures in human aortic aneurysms contribute to B-cell autoreactivity and inflammation.

GPCR-Ga13 signaling regulates survival of intestinal intraepithelialCD8 lymphocytes through migration to cytokine-rich niches

This study shows that GPCR-Ga13 signaling is essential for intestinal IEL survival by enabling migration to cytokine-rich niches, with loss of G13 leading to impaired function and increased disease severity.

CREB/CRTC2-Induced GPR65 Orchestrates Th17 Metabolic Fitness and Pathogenic Effector Function

This study identifies CREB/CRTC2 as a regulator of GPR65 in Th17 cells, showing its role in metabolic fitness and pathogenic function through RNA-seq and chromatin immunoprecipitation.

The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice

This study shows that the GPR4 antagonist NE-52-QQ57 improves survival, reduces inflammation, and lowers viral load in SARS-CoV-2-infected mice.

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.

This study shows that activating GPR65 on fibroblast-like synoviocytes leads to inflammatory mediator release, contributing to joint pain in mice and humans.