DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
Kaima Tsukada, Liudmyla Lototska, 絢 塚田, Ipek Ilgin Gönenç, Charlotte Sherlaw‐Sturrock, Manil Kanade, Antony W. Oliver, Samuel E. Jones, Satpal S. Jhujh, Julius Bannister, Asmat Ali, Muhammad Raza, Mathias Toft, Zafar Iqbal, Ambrin Fatima, , Andrew N. Blackford
The paper identifies DDIAS as a mitosis-specific DNA damage response protein that binds single-stranded DNA and is part of the TOPBP1-CIP2A complex, highlighting its role in protecting chromosome integrity during mitosis.
bioRxiv · Sep 9, 2025 · PreprintMolecular Biology