Antony W. Oliver

Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges

This study identifies how the BTRR complex assembles on ultrafine DNA bridges through SLiM recognition by RMI1-RMI2, revealing spatiotemporal regulation during DNA repair and segregation.

Structure-function studies of HRIKD-{triangleup}KI, a Minimal Kinase Domain of Human Heme-Regulated Inhibitor Kinase

The paper reports the structural analysis of a minimal kinase domain of HRI, showing its ligand-binding conformation and non-productive state, supporting drug discovery for blood cancer.

Condensin chromatin association is regulated by SMC head and hinge engagement and phosphorylation

This study investigates how ATP binding, hinge stability, and phosphorylation regulate condensin chromatin association in budding yeast using ChIP assays and kinase activity analysis.

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

The paper identifies DDIAS as a mitosis-specific DNA damage response protein that binds single-stranded DNA and is part of the TOPBP1-CIP2A complex, highlighting its role in protecting chromosome integrity during mitosis.

The Balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

This study identifies a centromere protection pathway in human mitotic cells that relies on strict mitotic inactivation of the BTRR complex through phosphorylation and kinase regulation.

The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress

The paper identifies RIF1-Long as a BRCA1 binding partner that enhances RAD51-dependent repair during DNA replication stress.

The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ

The paper identifies the CIP2A-TOPBP1 axis as a regulator of mitotic DNA repair pathways, showing it promotes MiDAS and MMEJ through distinct mechanisms.

TopBP1 utilises a bipartite GINS binding mode to support genome replication

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

CC-seq: Nucleotide-resolution mapping of Spo11 DNA double-strand breaks in S. cerevisiae cells

The paper introduces CC-seq, a method to map Spo11 DNA double-strand breaks with nucleotide-resolution in S. cerevisiae meiotic cells.

S. pombe Rtf2 is Important for Replication Fork Barrier Activity of RTS1 via Splicing of Rtf1

The paper shows that Rtf2 in S. pombe is essential for proper splicing of Rtf1, which is necessary for RTS1 barrier activity.

Inhibition of MRN activity by a telomere protein motif

The paper shows that the MIN motif in Rif2 inhibits MRN complex activity at telomeres, preventing DDR activation and NHEJ in yeast.

Live-cell single-molecule tracking highlights requirements for stable Smc5/6 chromatin association in vivo

The paper uses live-cell single-molecule tracking in fission yeast to show that Smc5/6 chromatin association depends on Nse6 and specific sub-pathways, with implications for homologous recombination.

A role of the Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6

This paper investigates the role of Nse4 kleisin and Nse1/Nse3 KITE subunits in the ATPase cycle of SMC5/6 complexes, showing their impact on complex stability and dynamics.