PathologyCell ReportsPeer-reviewed
Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart
Jessica Gambardella, Antonella Fiordelisi, Federica Andrea Cerasuolo…·Guido Iaccarino
This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.
DOI 10.1016/j.celrep.2026.118183