MoPaDi generates counterfactual explanations for histopathology images to reveal morphological features driving classifier predictions, improving interpretability in digital pathology.

Cancer Research · Jun 17, 2026Peer-reviewedBioinformatics

Transforming Histology into Virtual Multiplex Immunofluorescence to Decode Prognostic Spatial Immunity in Hepatocellular Carcinoma

Linghan Cai, Songhan Jiang, Junhao Liang, Fengchun Liu, Buyi Zhang, Nic Gabriel Reitsam, Qinghe Zeng, Zheqi Hu, Yanqing Ma, Ziqian Li, Shi Feng, Mo Hu, Xiuming Zhang, Jing Zhang, Jakob Nikolas Kather, , Wenjie Liang

HCCExplorer translates H&E slides into virtual multiplex immunofluorescence to identify prognostic spatial immune features in hepatocellular carcinoma.

bioRxiv · Feb 26, 2026 · PreprintPathology

Spatial dissection of ADC/RPT targets defines therapeutic opportunities inrhabdoid tumors

Nic Gabriel Reitsam, Victoria E. Fincke, Maria Daniela Hernandez Ramirez, Marlena Mucha, Éva Sipos, Lisa Siebenhüter, Johanna S. Enke, Maurice Loßner, Christian Vokuhl, Constantin Lapa, Martin Hasselblatt, Michael Frühwald, Bruno Märkl, Pascal David Johann

The paper identifies surface protein targets for ADC and RPT in rhabdoid tumors through transcriptomic and spatial analysis, revealing subgroup-specific expression patterns.

bioRxiv · Dec 13, 2025 · PreprintCancer Biology