Craig E. Brown

Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption

This study shows that reducing Serpine1 in endothelial cells after stroke improves recovery by reducing blood flow and preventing blood-brain barrier damage.

Angiogenesis in the mature mouse cortex is governed in a region specific and Notch1 dependent manner

The paper shows that angiogenesis in the adult mouse cortex is regionally specific and Notch1 dependent, with increased angiogenesis in posterior-lateral regions upon Notch1 knockdown.

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes

This study shows IL-10 signalling contributes to capillary stalling and cognitive impairment in type 1 diabetes by increasing vascular obstructions and reducing blood flow.

Sex and interferon gamma signalling regulate microglia migration in adult mouse cortex in vivo

This study shows that male and female microglia differ in migration behavior and that IFNγ signaling modulates this in males but not females following injury.

Optical opening of the blood brain barrier for targeted and ultra-sparse viral infection of cells in the mouse cortex

The paper describes a method to deliver viral vectors to specific brain regions in mice with high precision and minimal tissue damage.