Author

Chen-Hao Chen

Harvard UniversityORCID 0000-0002-0077-6795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Clifford A. MeyeriD· 2 shared Myles A BrowniD· 2 shared X. Shirley LiuiD· 2 shared Changxin WaniD· 1 shared Collin J. TokheimiD· 1 shared Han XuiD· 1 shared Jing‐Yu FaniD· 1 shared Jun S. LiuiD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenomics

Clifford A. MeyerORCID

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2 papers

Recent·Most cited

Determinants of transcription factor regulatory range

Chen-Hao Chen, Rongbin Zheng, Collin J. Tokheim, Xin Dong, Jing‐Yu Fan, Changxin Wan, Qin Tang, Myles A Brown, Jun S. Liu, Clifford A. Meyer, X. Shirley Liu

The paper identifies two classes of transcription factors based on their regulatory range and shows that long-range TFs' activity depends on chromatin state.

Nature Communications · May 18, 2020Peer-reviewedGenomics

Integrative analysis and refined design of CRISPR knockout screens

Chen-Hao Chen, Wei Li, Tengfei Xiao, Han Xu, Peng Jiang, Clifford A. Meyer, Myles A Brown, X. Shirley Liu

The paper introduces MAGeCK-NEST, a method to improve CRISPR screen analysis by integrating PPI data and refining sgRNA design, leading to better hit calling and library design.

bioRxiv · Feb 9, 2017 · PreprintBioinformatics