Tengfei Xiao

This study identifies dasatinib targets in T cell activation and proliferation using CRISPR/Cas9 screening in Jurkat cells, revealing both known and novel targets and their functional roles.

This paper develops methods to reduce false positives in CRISPR/Cas9 screens caused by copy number variations, improving screening accuracy.

The paper introduces MAGeCK-NEST, a method to improve CRISPR screen analysis by integrating PPI data and refining sgRNA design, leading to better hit calling and library design.