Xin Dong

This paper identifies CTHRC1 as a therapeutic target and serum biomarker for aortic dissection, showing it regulates VSMC phenotype and aortic integrity via the ERK1/2 pathway.

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

SCRIPro infers gene regulatory networks from single-cell and spatial multi-omics data, outperforming existing methods in reconstructing cell type-specific GRNs.

SELINA improves cell type annotation in single-cell RNA-seq by addressing batch effects and rare cell type characterization using domain adaptation and synthetic oversampling.

This paper introduces SCRIP, a method that integrates scATAC-seq and TR ChIP-seq data to infer single-cell TR activity and gene regulation networks, showing improved performance over existing methods.

TISCH provides an interactive web resource for visualizing single-cell transcriptomic data of the tumor microenvironment across multiple cancer types.

The paper identifies two classes of transcription factors based on their regulatory range and shows that long-range TFs' activity depends on chromatin state.

The paper fine-maps 77 GWAS loci in the human liver by integrating epigenetic and gene expression data to understand genetic and epigenetic regulation of gene expression.