Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes
Laura Mora-Bitria, Johnny Debebe, Kelly L. Miners, Kristin Ladell, Charandeep Kaur, James A. Traherne, Wei Jiang, David A. Price, Linda Hadcocks, Nicholas A. R. McQuibban, John Trowsdale, Florence Susan Wong, Nikolas Pontikos, Christoph Niederalt, Becca Asquith
The paper investigates how inhibitory KIRs modify HLA class II protective associations in Type 1 Diabetes, finding that iKIRs reduce HLA class II-mediated protection.
PLoS Genetics · Dec 26, 2024Peer-reviewedImmunology