Author

Sietske A.M. Sikkes

Amsterdam NeuroscienceORCID 0000-0002-0161-3656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Henne H. HolstegeiD· 3 shared Marc HulsmaniD· 3 shared Nina BekeriD· 2 shared Philip ScheltensiD· 2 shared Alida A. GouwiD· 1 shared Andrea B. GanziD· 1 shared Annemieke J.M. RozemülleriD· 1 shared August Benjamin SmitiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Henne H. HolstegeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Genetic & Genomic MedicineAlzheimer s Research & TherapyPeer-reviewedMar 6, 2025

TREM2 Risk Variants with Alzheimer Disease Differ in Rate of Cognitive Decline

Janna I.R. Dijkstra, Lisa Vermunt, Vikram Venkatraghavan…·Sven J. van der Lee

This study examines whether TREM2 risk variants in Alzheimer's disease patients lead to distinct clinical phenotypes, finding no baseline differences but faster cognitive decline in carriers.

18 citationstop 1%

humanbulk RNA-seq

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NeuroscienceEuropean Journal of EpidemiologyPeer-reviewedOct 25, 2018

The 100-plus Study of Dutch cognitively healthy centenarians: rationale, design and cohort description

Henne H. Holstege, Nina Beker, Tjitske Dijkstra…·Philip Scheltens

The 100-plus Study characterizes Dutch centenarians with preserved cognitive health, finding associations between APOE alleles and mortality, and higher education and socio-economic status.

91 citationstop 3%

humandatabase / resource

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NeuroscienceActa Neuropathologica CommunicationsPeer-reviewedJul 23, 2018

Neuropathology and cognitive performance in centenarians

Andrea B. Ganz, Nina Beker, Marc Hulsman…·Henne H. Holstege

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.

66 citationstop 3%

humanstatistical model

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