August Benjamin Smit

TMEM106B haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain

The paper examines TMEM106B haplotypes and their associations with tau and TDP-43 pathologies in aging brains using integrated multi-omics data.

A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain Samples

The paper compares whole-tissue and synaptosome proteomics using LC-MS/MS to evaluate synaptic protein detection, recommending a tiered approach for studying brain disorders.

NREM Oscillations Mediate Synaptic Proteome Remodelling to Support Synapse Stabilisation

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer's disease

This study shows that deleting GFAP and Vimentin in astrocytes reduces early synaptic and cognitive dysfunction in Alzheimer's mice by improving protein synthesis and astrocyte function.

Progressive remote memory decline coincides with parvalbumin interneuron hyperexcitability and enhanced inhibition of cortical engram cells in a mouse model of Alzheimer's disease

The paper shows that in a mouse model of Alzheimer's disease, remote memory decline with age is linked to increased inhibition of cortical engram cells by hyperexcitable parvalbumin interneurons.

One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation

This study develops a single-step transposon-based method to generate pure GABAergic neurons from iPSCs, showing they mature synaptically and form functional networks.

A foundational neuronal protein network model unifying multimodal genetic, transcriptional, and proteomic perturbations in schizophrenia.

The paper identifies three neuron-specific schizophrenia protein networks enriched for genetic and transcriptional perturbations and validates their disruption in 22q11.2 deletion carriers.

Intergenerational transmission of complex traits and the offspring methylome

The paper investigates how parental polygenic scores for complex traits are associated with offspring DNA methylation, finding significant links for schizophrenia, educational attainment, BMI, and height.

Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

This study shows Rab10 maintains Ca2+ homeostasis and protein synthesis to regulate neuropeptide release via DCVs in mouse hippocampal neurons.

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

Transcriptomic and genetic analysis suggests a role for mitochondrial dysregulation in schizophrenia

This study integrates genetic analysis with single nucleus RNA-seq to identify cell-type specific transcriptomic perturbations in schizophrenia, highlighting mitochondrial dysfunction and protein modification as key factors.

Immune-developmental processes contribute to schizophrenia risk: insights from a genetic overlap study with height

This study identifies 142 genes associated with both schizophrenia and height, finding enrichment in immune response genes and partial genetic overlap with white blood cell count.

Genetic Variants that Modulate Alzheimer's Disease Risk Deregulate Protein-Protein Correlations in the Gyrus Temporalis Medius

The paper identifies genetic variants associated with protein abundance and altered protein-protein correlations in the Gyrus Temporalis Medius in Alzheimer's Disease patients.

Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer's disease: age- and pathology-dependent effects on mitochondrial proteins

This study examines how early-life stress affects the synaptic proteome in Alzheimer's disease mouse models, revealing age- and pathology-dependent changes in mitochondrial and astrocytic proteins.

SNARE protein tomosyn regulates dense core vesicle composition but not exocytosis in mammalian neurons

This study shows that tomosyn regulates DCV cargo levels but not exocytosis in neurons, suggesting a role in cargo production rather than release.

Single-cell RNA sequencing data reveals rewiring of transcriptional relationships in Alzheimer's Disease associated with risk variants

The paper uses scRNA-seq data to identify gene expression rewiring in Alzheimer's Disease linked to risk variants by analyzing differential correlations across cell types.

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disorders

The paper identifies a protein-protein interaction network in human excitatory neurons for 13 ASD risk genes, revealing novel interactions and convergent mechanisms contributing to autism spectrum disorders.

Transcriptional diversity in synaptic gene sets is sufficient to discriminate cortical neuronal identity

The paper identifies synaptic gene sets that can discriminate cortical neuronal identities with the same power as all genes, revealing functional categories and compartments with cell type-specific expression.

Proximity of astrocyte leaflets to the synapse determines memory strength

This study shows that astrocyte leaflet structure, regulated by Ezrin, affects memory strength by controlling glutamate diffusion and synaptic function in the hippocampus.

β-amyloid-driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3

This study shows that β-amyloid oligomers cause synaptic depression by removing GluA3-containing AMPARs from synapses, requiring PDZ protein interaction.

Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development

The paper identifies brain-region specific splicing patterns at single-cell and spatial resolution in postnatal mice, revealing cell-type specific and region-specific isoform expression.

From stress to depression: Development of extracellular matrix-dependent cognitive impairment following social stress

This study investigates how social stress leads to cognitive impairment and affective disturbances in rats, revealing distinct phases of hippocampal extracellular matrix remodeling associated with different aspects of depression.

Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process

The paper shows astrocytes have a translational response to neuronal activity, altering their proteome at synapses through BDNF and K+ signals.

Gpr158 deficiency impacts hippocampal CA1 neuronal excitability, dendritic architecture, and affects spatial learning

This study shows that Gpr158 deficiency in mice leads to impaired spatial memory and altered CA1 neuronal excitability and dendritic structure.

Specific nanoscale synaptic reshuffling and control of short-term plasticity following NMDAR- and P2XR-dependent Long-Term Depression

The paper investigates nanoscale synaptic changes during two LTD protocols, showing NMDAR-dependent LTD reorganizes PSD-95 to enhance synaptic facilitation.

The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity

This study shows that CYFIP1 haploinsufficiency in mice causes reduced brain functional connectivity and white matter defects, linking it to neuropsychiatric disorders like Autism and Schizophrenia.

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways

This study identifies 202 genome-wide significant loci for insomnia using a large sample, linking them to specific brain cell types and pathways.

Integrative analysis of rare variants and pathway information shows convergent results between immune pathways, drug targets and epilepsy genes

The paper introduces a Bayesian framework to prioritize risk genes for complex diseases by integrating gene-set information with variant counts, identifying novel epilepsy risk genes and linking them to immune pathways and drug targets.

Single-cell isoform RNA sequencing (ScISOr-Seq) across thousands of cells reveals isoforms of cerebellar cell types.

The paper introduces ScISOr-Seq, a method combining single-cell full-length cDNA amplification with short-read and long-read sequencing to identify isoforms in cerebellar cell types across thousands of cells.

Neuropathology and cognitive performance in centenarians

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.