Annemieke J.M. Rozemüller

The paper shows that APP-CTFβ regulates glutamatergic synaptic transmission and that Aβ counteracts its hyperexcitability effects in Alzheimer's disease.

The paper examines TMEM106B haplotypes and their associations with tau and TDP-43 pathologies in aging brains using integrated multi-omics data.

This study uses correlative light and electron microscopy to characterize the ultrastructural changes in tau fibrils during ghost tangle formation in Alzheimer's disease brain tissue.

The paper integrates genotype, clinical, and neuropathological data from 2,553 donors to show genetic risk overlaps across brain disorders and neuropsychiatric symptoms.

The paper identifies foamy microglia as contributors to disease progression in secondary progressive MS, linking oxylipins to lesion expansion and proposing monoacylglycerol lipase as a therapeutic target.

The paper identifies oxidized MIF as a drug target that links HSV-1 infection and external stressors to tau pathology in Alzheimer's disease.

The paper identifies genetic variants associated with protein abundance and altered protein-protein correlations in the Gyrus Temporalis Medius in Alzheimer's Disease patients.

The paper quantifies regional synaptic degeneration in Parkinson's Disease and Dementia with Lewy bodies, linking it to alpha-synuclein burden, axonal damage, and clinical outcomes.

This study examines how Alzheimer's disease pathology in dementia with Lewy bodies correlates with astroglial α-synucleinopathy and regional differences in pathology load and morphology.

This study uses diffusion MRI and histopathology to show that microstructural changes in the substantia nigra and its tracts in Parkinson's disease correlate with dopaminergic loss and Lewy neurite pathology.

This study examines the regional distribution of neurofilaments in Parkinson's disease and its association with pathological markers and MRI measures of brain atrophy and diffusivity.

The paper examines how structural connectivity changes relate to cholinergic cell density in the nucleus basalis of Meynert in Alzheimer's disease, finding specific associations in amnestic cases.

This study identifies histopathological correlates of MRI cortical atrophy in Alzheimer's disease, finding that phosphorylated-tau and reactive microglia loads strongly correlate with atrophy in specific brain regions.

The paper uses high-resolution imaging and biophysical methods to show that Lewy pathology in Parkinson's disease consists mainly of a crowded membranous medley of vesicles and dysmorphic organelles, with only a small fraction containing proteinaceous filaments.

This study examines neuropathological hallmarks in centenarians' brains and their association with cognitive performance, finding that some pathologies correlate with lower cognitive test results.

This study examines the distribution of α-synuclein pathology in insular cortex sub-regions in Parkinson’s disease and dementia with Lewy bodies, revealing regional differences in vulnerability.