Isabelle K. Gorham

Acute exposure to cell-free mitochondrial DNA induces pregnancy-specific aortic endothelial dysfunction and organ-selective inflammation in rats

This study shows that acute exposure to cell-free mitochondrial DNA in pregnant rats causes aortic endothelial dysfunction and organ-specific inflammation, with partial TLR9 involvement.

Fetal sex shapes placental inflammatory responses to extracellular mitochondrial DNA

This study shows that extracellular mitochondrial DNA induces sex-specific placental inflammation in rats, mediated partially by TLR9, with lasting effects on antioxidant enzymes and stillbirth risk.

Gestational Chronic Intermittent Hypoxia Triggers Maternal Inflammation and Disrupts Placental Stress Responses

This study shows that gestational chronic intermittent hypoxia increases maternal inflammation, alters EV characteristics, and disrupts placental stress responses in rats without affecting fetal growth.