A lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity
Farnaz Mohammadi, Shakthi Visagan, Sean M. Gross, Luka Karginov, J. C. Lagarde, Laura M. Heiser, Aaron S. Meyer
This paper introduces a lineage tree-based hidden Markov model to quantify cellular heterogeneity and plasticity using single-cell lineage data, showing it can classify distinct phenotypic states and drug responses in cancer and non-cancer cell populations.
bioRxiv · Jun 25, 2021 · PreprintSystems Biology