A Novel Model for Proton Transport Mediated by Uncoupling Protein 1
Luise Jacobsen, Sneha Menon, Michael James Gaudry, Ali Asghar Hakami Zanjani, Peter Reinholdt, Martin Jastroch, Himanshu Khandelia
This study reveals the mechanism of UCP1-mediated proton and fatty acid transport using molecular simulations and mutagenesis, showing how proton transfer and FA movement are facilitated by specific residues and conformational changes.
Protein Science · Oct 29, 2025Peer-reviewedBiophysics