Author

Alan M. Rice

Trinity College DublinORCID 0000-0002-0226-6449Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

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Aoife McLysaghtiD· 1 shared Pauric DonnellyiD· 1 shared Yuanshuo LiiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperEvolutionary Biology

Aoife McLysaghtORCID

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1 paper

Recent·Most cited

Evolutionary BiologyGenome Biology and EvolutionPeer-reviewedJul 4, 2025

Evolution of dosage-sensitive genes by tissue-restricted expression changes

Alan M. Rice, Yuanshuo Li, Pauric Donnelly, Aoife McLysaght

The paper investigates how dosage-sensitive genes evolve by showing they are more likely to have tissue-specific expression changes due to eQTLs, avoiding conflicts with expression constraints in other tissues.

5 citations

humanbulk RNA-seq

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