Aoife McLysaght

The paper analyzes a duplicate-resolved paddlefish genome to study rediploidisation and Hox cluster evolution, finding links between genome rearrangements, 3D architecture, and rediploidisation timing.

This paper develops an automated pipeline to reconstruct ancestral chromosomes before and after whole genome duplications using gene content conservation.

This study analyzes hypodiploid tumors across 34 cancer types, finding widespread chromosomal instability and distinct evolutionary patterns, with implications for prognosis and risk stratification.

This paper identifies INTS12's role in stabilizing the Integrator-NELF complex to prevent the release of defective RNA Polymerase II complexes, showing its importance in transcription regulation and cellular toxicity.

The paper investigates how dosage-sensitive genes evolve by showing they are more likely to have tissue-specific expression changes due to eQTLs, avoiding conflicts with expression constraints in other tissues.

The paper shows that clitellates experienced a burst of genomic rearrangements leading to loss of macrosynteny with marine annelids and new chromosomal interactions.