Author

Xiang Zhuang

Zhejiang UniversityORCID 0000-0002-0253-1476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Organism:human· 1 Approach:large language model· 1

Frequent Co-Authors

Huajun CheniD· 3 shared Haihong Yang· 2 shared Jie LiaoiD· 2 shared Junyun ChengiD· 2 shared Ningyu ZhangiD· 2 shared Penghui YangiD· 2 shared Xiaohui FaniD· 2 shared Xiaoyan LuiD· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBioinformatics

Huajun ChenORCID

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Author profile →

3 papers

Recent·Most cited

Multi-purpose controllable protein generation via prompted language models

Zeyuan Wang, Binbin Chen, Keyan Ding, Jiawen Cao, Ming Qin, Yadan Niu, Xiang Zhuang, Xiaotong Li, Kehua Feng, Tong Xu, Ningyu Zhang, Haoran Yu, Qiang Zhang, Huajun Chen

This paper introduces PROPEND, a protein design method using prompted language models to directly control multiple properties, achieving higher functional recovery than traditional pipelines.

bioRxiv · Nov 17, 2024 · PreprintSynthetic Biology

De novo analysis of bulk RNA-seq data at spatially resolved single-cell resolution

Jie Liao, Jingyang Qian, Fang Yin, Zhuo Chen, Xiang Zhuang, Ningyu Zhang, Xin Shao, Yining Hu, Penghui Yang, Junyun Cheng, Yang Hu, Lingqi Yu, Haihong Yang, Jinlu Zhang, Xiaoyan Lu, , Xiaohui Fan

Bulk2Space deconvolves bulk RNA-seq data to reveal spatial and cellular heterogeneity using single-cell and spatial transcriptomics references, identifying immune cell spatial variance and novel gene patterns in mouse brain regions.

Nature Communications · Oct 30, 2022Peer-reviewedBioinformatics

Reference-free Cell-type Annotation for Single-cell Transcriptomics using Deep Learning with a Weighted Graph Neural Network

Xin Shao, Haihong Yang, Xiang Zhuang, Jie Liao, Penghui Yang, Penghui Yang, Junyun Cheng, Xiaoyan Lu, Huajun Chen, Xiaohui Fan

scDeepSort is a reference-free cell-type annotation tool for scRNA-seq data that outperforms reference-dependent methods in accuracy across human and mouse datasets.

Nucleic Acids Research · Sep 8, 2021Peer-reviewedBioinformatics