Xiaoyan Lu

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

Bulk2Space deconvolves bulk RNA-seq data to reveal spatial and cellular heterogeneity using single-cell and spatial transcriptomics references, identifying immune cell spatial variance and novel gene patterns in mouse brain regions.

SpaTalk infers cell-cell communication from spatial transcriptomic data using a knowledge graph and graph network, outperforming existing methods on public datasets and revealing insights into tissue communication mechanisms.

The paper constructs a single-cell transcriptomic atlas of transplanted livers and identifies an EAD-associated pathogenic cellular module.

scDeepSort is a reference-free cell-type annotation tool for scRNA-seq data that outperforms reference-dependent methods in accuracy across human and mouse datasets.

The paper constructs a single-cell transcriptomic atlas of liver non-parenchymal cells in healthy and diseased mice, identifying disease-specific heterogeneity and functional changes.