Sialylation of Asparagine 612 inhibits Aconitase activity during mouse sperm capacitation; A possible mechanism for the switch from oxidative phosphorylation to glycolysis
Ana Izabel Silva Balbin Villaverde, Rachel Anne Ogle, Peter John Lewis, Louise Hetherington, Vince Carbone, Tony Velkov, Jacob Kendal Netherton, Mark A. Baker
The paper identifies sialylation changes in mouse sperm during capacitation, showing that sialylation of ACO2 inhibits its activity, potentially driving the metabolic switch from oxidative phosphorylation to glycolysis.
Molecular & Cellular Proteomics · Aug 24, 2020Peer-reviewedDevelopmental Biology