Peter John Lewis

Structural basis of the nucleotide incorporation cycle of bacterial DNA polymerase III

This study determines cryo-EM structures of bacterial DNA polymerase III complexes to elucidate the mechanism of nucleotide incorporation and proofreading.

Multiple classes and isoforms of the RNA polymerase recycling motor protein HelD

The paper investigates the phylogenetic diversity of HelD proteins, identifying three classes and multiple isoforms, some linked to antibiotic resistance.

RNA polymerases from Low G+C Gram Positive Bacteria

This paper reviews recent structural studies of RNA polymerase in low G+C Gram positive bacteria, focusing on Bacillus subtilis and potential antimicrobial targets.

Sialylation of Asparagine 612 inhibits Aconitase activity during mouse sperm capacitation; A possible mechanism for the switch from oxidative phosphorylation to glycolysis

The paper identifies sialylation changes in mouse sperm during capacitation, showing that sialylation of ACO2 inhibits its activity, potentially driving the metabolic switch from oxidative phosphorylation to glycolysis.