Casim A. Sarkar

This study shows that p53 oscillations can be entrained by periodic DNA damage stimuli, leading to synchronized cell responses and altered cell-fate outcomes.

The paper investigates how cell state velocity influences quiescence-proliferation fate decisions in breast cancer under hypoxia, finding that inertia, not initial position, determines cell fate.

MVsim quantifies and designs multivalent interactions using a configurational network model, demonstrating its utility through simulations and analysis of protein logic gates and SARS-CoV-2 binding.

The paper develops a computational and experimental method to predict and engineer DNA sequences that control site-specific recombination rates for synthetic biology applications.