In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles
Martin Bartas, Václav Brázda, Natália Bohálová, Alessio Cantara, Adriana Volná, Tereza Stachurová, Kateřina Malachová, Eva B. Jagelská, Otília Porubiaková, Jiří Červeň, Petr Pečínka
The paper analyzes coronavirus genomes to identify noncanonical nucleic acid structures, finding enriched inverted repeats and G-quadruplex sites that may regulate viral RNA packaging and suggest potential drug targets.
Frontiers in Microbiology · Jul 3, 2020Peer-reviewedBioinformatics