Václav Brázda

This study identifies the NS3 protease domain of Yellow Fever Virus as a high-affinity G4 binder, revealing its interaction mechanism and potential as an antiviral target.

This study identifies and validates G-quadruplex-forming sequences in archaea, demonstrating their presence and function in vivo and identifying potential resolving enzymes.

This study identifies potential protein-coding regions in negative-sense RNA intermediates of SARS-CoV-2 using bioinformatics and structural analysis.

The paper analyzes coronavirus genomes to identify noncanonical nucleic acid structures, finding enriched inverted repeats and G-quadruplex sites that may regulate viral RNA packaging and suggest potential drug targets.

The paper investigates amino acid variations in p53 across species and finds correlations between specific substitutions and extended lifespan.