Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia
Zachary D. Michel, Layne N. Raborn, Tiahna Spencer, Kristen S. Pan, Daniel Martín, Kelly Lauter Roszko, Yan Wang, Pamela Gehron Robey, Michael Terrence Collins, Alison M. Boyce, Luis F de Castro
This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.
Cells · Apr 30, 2024Peer-reviewedPathology