SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
Su Datt Lam, Nicola Bordin, Vaishali Waman, Harry M. Scholes, Paul Ashford, Neeladri Sen, Lucy van Dorp, Clemens Rauer, Natalie L. Dawson, Camilla Pang, Mahnaz Abbasian, Ian Sillitoe, Sarah Edwards, Franca Fraternali, Jonathan Gill Lees, , Christine Anne Orengo
The paper predicts SARS-CoV-2 spike protein interactions with ACE2 orthologues across 215 vertebrates, finds mutations in ACE2 are more detrimental, and shows human strains are present in animals.
Scientific Reports · Oct 5, 2020Peer-reviewedBioinformatics