Author
Institute of Structural and Molecular BiologyORCID 0000-0003-4772-7656Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Vaishali Waman, Paul Ashford, Su Datt Lam…·Christine Anne Orengo
The paper predicts human and viral protein variants that enhance SARS-CoV-2 binding affinity and may increase COVID-19 susceptibility.
Catarina Inês Mendes, Emma Griffiths, Alexander Manuele…·Finlay Maguire
hAMRonization standardizes AMR gene detection outputs from multiple tools into a unified format for easier analysis and integration.
Vaishali Waman, Jialin Yin, Neeladri Sen…·Christine Anne Orengo
The paper characterizes structural and functional motifs of ATP-PPase substrate-specificity groups using structural data to inform antibacterial drug design.
Nicola Bordin, Ian Sillitoe, Vamsi Nallapareddy…·Christine Anne Orengo
The paper uses AlphaFold2 to analyze protein structures from 21 organisms, identifying 26 novel superfamilies and expanding structural diversity insights.
Cedric C.S. Tan, Su Datt Lam, Damien Richard…·François Balloux
The paper analyzes SARS-CoV-2 genomic mutations in mink and deer to identify potential host-specific adaptations and assess spillover risks.
Su Datt Lam, Vaishali Waman, Christine Anne Orengo, Jonathan Gill Lees
The paper investigates how insertions in the SARS-CoV-2 Spike N-terminal domain may enhance sialic acid binding and contribute to increased transmissibility.
Su Datt Lam, Nicola Bordin, Vaishali Waman…·Christine Anne Orengo
The paper predicts SARS-CoV-2 spike protein interactions with ACE2 orthologues across 215 vertebrates, finds mutations in ACE2 are more detrimental, and shows human strains are present in animals.
Su Datt Lam, Christine Anne Orengo, Jonathan Gill Lees
The paper analyzes the structural and functional implications of mutually exclusive splicing across animal genomes, finding that these events are enriched in surface-exposed residues and near functional sites.