Brian W. Brunelle

The paper develops and validates a set of 100,000 RNA baits (CryptoCap_100k) to enrich Cryptosporidium DNA from clinical and environmental samples, improving read mapping, coverage, and variant analysis while reducing costs.

This study evaluates target-enrichment sequencing for generating genomic data from difficult-to-culture bacteria, showing it can produce high-quality data with sufficient coverage for variant calling.