A de novo CO2 Reductase Featuring a Cysteine-Ligated Cobalt Porphyrin Cofactor
Emily Radley, Alessia Andrews, Indrek Kalvet, Yunling Deng, Elizabeth L. Bell, Colin Levy, Mary Ortmayer, Derren J. Heyes, Clare F. Megarity, Reyes Núñez‐Franco, Amy E. Hutton, Yi Lu, David A. Baker, Anthony P. Green
This paper designs and tests hyper-thermostable CO2 reductases with cobalt porphyrin cofactors, achieving high activity and suppressing competing reactions.
Journal of the American Chemical Society · Jul 9, 2026Peer-reviewedBiochemistry