Yi Lu

This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.

The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.

This paper designs and tests hyper-thermostable CO2 reductases with cobalt porphyrin cofactors, achieving high activity and suppressing competing reactions.

This study uses 3D hydrogel models to investigate how extracellular matrix, hypoxia, and neuronal cells affect glioblastoma radiosensitivity, identifying potential strategies to improve treatment.

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

This paper introduces a fluorescence-lifetime-based multiplexed detection strategy using fluorogenic aptamers to distinguish viral RNA targets with minimal cross-reactivity and spectral overlap.