Author

Edith L. Pfister

Sanofi (United States)ORCID 0000-0002-0345-7773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Adel BoudiiD· 1 shared Anastasia KhvorovaiD· 1 shared Bruno M.D.C. GodinhoiD· 1 shared Christian MuelleriD· 1 shared Dimas EcheverriaiD· 1 shared Ellen SappiD· 1 shared Emily G. KnoxiD· 1 shared Eugenia LyashenkoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Adel BoudiORCID

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2 papers

Recent·Most cited

Prediction of Adeno-Associated Virus Fitness with a Protein Language Based Machine Learning Model

Jason Wu, Yu Qiu, Eugenia Lyashenko, Tess Torregrosa, Edith L. Pfister, Michael J. Ryan, Christian Mueller, Sourav Choudhury

The paper develops a machine learning model to predict AAV capsid fitness from amino acid sequences, achieving high accuracy and generalizability across datasets.

Human Gene Therapy · Apr 17, 2025Peer-reviewedBioinformatics

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS

Faith Conroy, Rachael Miller, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Bruno M.D.C. Godinho, Emily G. Knox, Ellen Sapp, Jaquelyn Sousa, Ken Yamada, Farah Mahmood, Adel Boudi, Kimberly B. Kegel-Gleason, Marian DiFiglia, Neil Aronin M. D, , Edith L. Pfister

This paper demonstrates allele-specific siRNA silencing of mutant huntingtin in CNS using SNP-based targeting in vitro and in vivo.

bioRxiv · Jun 29, 2022 · PreprintNeuroscience