Alberto Ferrús

The haplolethality paradox of the wupA gene in Drosophila

This paper investigates the haplolethal region of the Drosophila wupA gene, showing that haplolethality arises from the combined insufficiency of multiple TnI isoforms requiring chromosomal integrity for proper expression.

The ubiquitin ligase Ariadne-1 regulates NSF for neurotransmitter release

This study identifies Comt/NSF as an ubiquitination substrate of Ari-1 in Drosophila neurons and shows that Ari-1 loss of function affects neurotransmitter release differently in spontaneous and evoked modes.

PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposits formation

This study shows that PI3K activation prevents Aβ42-induced synapse loss and promotes amyloid deposit formation in Drosophila and human cell cultures.