Author

Tina Giese

Denali Therapeutics (United States)ORCID 0000-0002-0352-9191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Anastasia G. HenryiD· 1 shared Annie ArguelloiD· 1 shared Buyankhishig TsogtbaatariD· 1 shared Cathal S. MahoniD· 1 shared Darren Chan· 1 shared Do Jin KimiD· 1 shared Dolores DiaziD· 1 shared Elliot R. ThomseniD· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anastasia G. HenryORCID

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1 paper

Recent·Most cited

Molecular architecture determines brain delivery of a transferrin-receptor targeted lysosomal enzyme

Annie Arguello, Cathal S. Mahon, Meredith Calvert, Darren Chan, Jason C. Dugas, Michelle E. Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A. Damo, Joseph N. Duque, Timothy Earr, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, , Mihalis S. Kariolis

The paper compares brain delivery and efficacy of two TfR-targeted enzyme fusions in MPS II mice, finding the moderate-affinity ETV:IDS has better brain exposure and substrate reduction than the high-affinity IgG:IDS.

The Journal of Experimental Medicine · Dec 17, 2021Peer-reviewedNeuroscience