Author

Lei Guo

The University of Texas Southwestern Medical CenterORCID 0000-0002-0402-4152Unclaimed ORCID profile · follow to get notified of new preprints

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Lei Guo5 papers · The University of Texas Southwestern Medical Center

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Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Guanghua XiaoiD· 1 shared Jiayi WangiD· 1 shared Lin XuiD· 1 shared Lin ZhongiD· 1 shared Qiwei LiiD· 1 shared Xi JiangiD· 1 shared Yanghong Guo· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Guanghua XiaoORCID

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1 paper

Recent·Most cited

GenomicsBriefings in BioinformaticsPeer-reviewedMar 1, 2026

SpaFun: Discovering Domain-specific Spatial Expression Patterns and New Disease-Relevant Genes using Functional Principal Component Analysis

Xi Jiang, Yanghong Guo, Lei Guo…·Lin Xu

SpaFun identifies domain-representative genes in spatial transcriptomics data using functional principal component analysis, outperforming existing methods in accuracy and efficiency.

DOI 10.1093/bib/bbag150

spatial transcriptomicsstatistical model

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