Author

Lei Guo

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Denise M. O. RamireziD· 2 shared Diana D. ShiiD· 2 shared Feng CaiiD· 2 shared Kalil G. AbdullahiD· 2 shared Lauren G. ZachariasiD· 2 shared Michael M. LevittiD· 2 shared Milan R. SavaniiD· 2 shared Pranita KaphleiD· 2 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

Denise M. O. RamirezORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth

Kalil G. Abdullah, Kenji Miki, Charles K. Edgar, Shuangcheng Alivia Wu, Yi Xiao, Yuan-Tai Huang, Richard Drexler, Saritha Krishna, Vineshkumar Thidil Puliyappadamba, Li Wei Rachel Tay, Fanen Yuan, Milan R. Savani, Maged T Ghoche, Shawn E. Kotermanski, Jeffrey Isaac Traylor, , Samuel K. McBrayer

This study identifies GAA accumulation in gliomas as a driver of neuronal activity and tumor growth, linking cancer metabolism to neuroscience through GABAA receptor activation.

Cell · Sep 1, 2026Peer-reviewedCancer Biology

Ten-Fold Expansion MALDI Mass Spectrometry Imaging of Tissues and Cells at 500 nm Resolution

Chengyi Xie, Jianing Wang, Lei Guo, Xin Diao, Thomas Ka Yam Lam, Yanyan Chen, Ruxin Li, Yue Zhang, Xiaoxiao Wang, Jiacheng Fang, Zhong‐Ping Yao, Klaus Dreisewerd, Zongwei Cai

This paper introduces a novel MALDI-MSI method achieving 500 nm resolution for subcellular imaging in mouse brain tissues and cultured cells.

Angewandte Chemie International Edition · Aug 7, 2026Peer-reviewedBiochemistry

The Ser83, Arg85, Tyr88, Asn124, Lys192 of C-terminal Lipid-associated membrane hemagglutinin affecting Mycoplasma synoviae agglutination of erythrocyte

Si Duoduo, Shijun Bao, Lei Guo, Xiu-Hong Chen, Feng-Qin Wong, Xiao Xiao He, Qing Wang, Yuan Shi, Shenghu null He, Ji dong Li

This study identifies five key amino acid residues in Mycoplasma synoviae LAM HA critical for hemagglutination activity and shows their role in pH-sensitive structural stability.

bioRxiv · Apr 9, 2026 · PreprintMicrobiology

REST-AKT-SOX2 axis controls neuronal lineage state and Midkine-mediated communication in SHH-medulloblastoma.

Ashutosh Singh, Lei Guo, Jyothishmathi Swaminathan, Donghang Cheng, Yan Yang, Swarnalatha Manickavinayaham, Lori Xu, Vidya Gopalakrishnan

This study identifies the REST-AKT-SOX2 axis as a key regulator of stem/progenitor identity and Midkine-mediated communication in SHH medulloblastoma, highlighting it as a potential therapeutic target.

bioRxiv · Apr 9, 2026 · PreprintCancer Biology

Mutant IDH silences GSX2 to reprogram neural progenitor cell fate and promote gliomagenesis

Yi Xiao, Diana D. Shi, Lei Guo, Ethan Neumann, Michael M. Levitt, Pranita Kaphle, Tracey E. Shipman, Haocheng Li, Feng Cai, Denise M. O. Ramirez, Lauren G. Zacharias, Zhenkang Chen, Mathew Lin, Vineshkumar Thidil Puliyappadamba, Tao Chen, , Samuel K. McBrayer

This study shows mutant IDH reprograms neural progenitor cell fate by silencing Gsx2, promoting gliomagenesis through lineage switching.

bioRxiv · Aug 12, 2025 · PreprintCancer Biology