Pitfalls in estimating and interpreting the contribution of ultra-rare genetic variants to the heritability of complex traits
Huanwei Wang, Pierrick Wainschtein, Julia Sidorenko, Mulusew Fikere, Yuanxiang Zhang, Kathryn E. Kemper, Zhili Zheng, Valentin Hivert, Jian Zeng, Michael Edward Goddard, Peter M. Visscher, Loïc Yengo
The paper identifies biases in estimating heritability from ultra-rare variants and shows that accounting for these biases reveals significant heritability estimates for several traits.
medRxiv · Apr 7, 2026 · PreprintGenetic & Genomic Medicine